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178 Patients with obstructive sleep apnea syndrome (OSA) or nocturnal hypoxemia (NH), both of which are characterized by recurrent hypoxia, tend to develop circadian rhythm disorders due to enhanced HIF-1 gene expression mediated by hypoxia in OSA

et al., 2022) showed that by activating GABAB receptors and regulating the AKT/GSK 3 /-catenin signaling pathway, the expression of SLC7A11 and GPX4 could be increased, alleviating brain edema, OS, and BBB damage, and inhibiting neuronal ferroptosis

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Briefly, 25 L reaction volume, cDNA (5 L) was mixed with SYBR-Green mixture (12.5 l), primer (2 l), and RNase free water (5.5 l) (Table S2)